From Milan:
A9 Motorway LAGO DI COMO exit
(the last exit in Italy)
continue for about 25 km towards
Menaggio (SS340)

from Lugano:
A2 Motorway direction Italia,
LAGO DI COMO exit
(the first exit in Italy)
continue for about 25 km towards
Menaggio (SS340)

from Malpensa:
A8 Motorway direction Milano,
follow A9 Motorway direction Como,
exit LAGO DI COMO,
(the last exit in Italy)
continue for about 25 km towards
Menaggio (SS340)